In a large bowl, combine ground beef, panko, onion, eggs, soy sauce, sesame oil, garlic, fresh ginger, ground ginger, optional red pepper flakes, and black pepper. Mix gently and roll into 1-inch meatballs.
Whisk together chicken broth, soy sauce, brown sugar, honey, cornstarch mixed with cold water, rice vinegar, sesame oil, ground ginger, and minced garlic for the sauce.
Place the meatballs in the crockpot and pour the sauce over them. Cook on low for 6-8 hours or high for 3-4 hours until cooked through.
If the sauce needs thickening after cooking, remove a portion of the sauce to mix with cornstarch before returning it to the crockpot for an additional 30 minutes.
Serve over cooked rice and garnish with chopped green onions and sesame seeds.